Public Deliverables

WP1 – Prevalence of insulin-signalling multimorbidity across the lifespan

• D1.2 – Report on the association of compulsive traits and/or cognitive rigidity with insulin signalling markers and/or somatic insulin-related disorders in participants of the UK Biobank
• D1.3 – Report on the effect of insulin signalling markers on cognitive impairment and AD biomarkers
• D1.4 – Report on familial co-aggregation of insulin-related morbidities and compulsivity disorders in a multi-generational nationwide cohort-study
• D1.6. – Report on incidence, risk, time trends and lifetime course of compulsive and (non-compulsive) brain disorders in Danish individuals with and without insulin-related morbidities

WP2 – Mechanism validation and refinement in animal models

• D2.1. – Report on comorbidity of compulsivity, learning difficulties, and diabetes in TALLYHO mice

WP4 – Mechanism validation and refinement at the genetic and genomic level

• D4.1 – Report on the genetic overlap between somatic and neurodegenerative brain insulinopathies and related traits
• D4.2. – Report on epigenetic analysis of insulinopathies

WP6 – Clinical guidelines, policy, and dissemination

• D6.1 – Communication and outreach plan

WP8 – Project Management

• D8.1 – Go-online of the public project website